Archiv der Pharmazie p. 12 - 16 (1997)
Update date:2022-07-30
Topics:
Ruecker, Gerhard
Breitmaier, Eberhard
Manns, Detlef
Maier, Walter
Marek, Anne
Heinzmann, Berta
Heiden, Klemens
Seggewies, Stephan
1,4-Epidoxy-bisabola-2,12-dien (3) and aromatic hydroperoxides (4, 5) were prepared by photoxidation of γ-curcumene (1). Reduction and esterification of 6 and 7 afforded compounds 9 to 10. All compounds were tested in vitro for antimalarial activity. The activity could not be increased significantly, compared with 3. The most active compounds, 3 and 9, did not show in vivo antimalarial activity in mice.
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Doi:10.1002/hlca.19970800324
(1997)Doi:10.1016/j.tetlet.2006.09.032
(2006)Doi:10.1021/acs.orglett.8b03394
(2019)Doi:10.1016/j.bmcl.2010.08.056
(2010)Doi:10.1055/s-2004-836036
(2005)Doi:10.1002/anie.200703886
(2007)
