Tetrahedron Letters p. 3679 - 3682 (1997)
Update date:2022-08-04
Topics:
Bhatt, Ulhas
Mohamed, Nazim
Just, George
Roberts, Edward
Two routes for the synthesis of derivatized oxopiperazines, which may act as constrained peptide mimics, are reported. The syntheses employ reductive amination and sulfonamide approaches for generating N-allylic amino acid ester derivatives and utilizing them for assembling the ring systems. An aspartame analog was prepared using this methodology.
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