Derivatized oxopiperazine rings from amino acids

Article abstract of DOI:10.1016/S0040-4039(97)00726-0

Two routes for the synthesis of derivatized oxopiperazines, which may act as constrained peptide mimics, are reported. The syntheses employ reductive amination and sulfonamide approaches for generating N-allylic amino acid ester derivatives and utilizing them for assembling the ring systems. An aspartame analog was prepared using this methodology.