Aspartame dipeptide analogues: Effect of number of side-chain methylene group spacers and C(α)-methylation in the second position

DOI: 10.1016/S0957-4166(97)00127-4

Source and publish data:

Tetrahedron Asymmetry p. 1305 - 1314 (1997)

Update date:2022-08-04

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Authors:

Mossel, Eric

Formaggio, Fernando

Crisma, Marco

Toniolo, Claudio

Broxterman, Quirinus B.

Boesten, Wilhelmus H.J.

Kamphuis, Johan

Quaedflieg, Peter J.L.M.

Temussi, Piero

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Article abstract of DOI:10.1016/S0957-4166(97)00127-4

Our model of the active site of the sweet taste receptor is shown to be consistent with the aspartame analogues in which the L-Phe² residue is replaced by L-(αMe)Phg, L-(αMe)Phe or L-(αMe)Hph. The analogues containing either the first or the th

Full text of DOI:10.1016/S0957-4166(97)00127-4

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