Bioorganic and Medicinal Chemistry Letters p. 1007 - 1012 (1997)
Update date:2022-08-05
Topics:
Tatlock, John H.
Linton, M. Angelica
Hou, Xinjun J.
Kissinger, Charles R.
Pelletier, Laura A.
Showalter, Richard E.
Tempczyk, Anna
Villafranca, J. Ernest
The design, synthesis, and evaluation of small molecule, in vitro, inhibitors of human calcineurin is described. These ligands were derived from the known nonspecific phosphatase inhibitor endothall, and were modified to enhance binding and selectivity toward calcineurin using protein crystal structure information.
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Doi:10.1016/S0022-328X(00)00772-5
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(1997)
