Enzymatic resolution of α,β-diacetoxysulfides: Synthesis of optically active O,S-acetals by regiospecific enantioselective primary acetate hydrolysis

Article abstract of DOI:10.1016/S0040-4039(97)00672-2

α,β-Diacetoxy sulphides are precursors of chiral oxathiolanes and have been resolved by Pseudomonas fluorescens lipase catalysed hydrolysis. The resolution proceeds with complete regioselectivity for the primary acetate and excellent enantioselectivity in most cases.