The novel synthesis of the protease inhibitor (S)-1-chloro-3-[(p-tolylsulfonyl)amino]-7-amino-2-[5,5,6,6-3H]heptanone ([3H]T:CK labeled to high specific activity with tritium

Article abstract of DOI:10.1002/(SICI)1099-1344(199705)39:5<379::AID-JLCR981>3.0.CO;2-I

The protease inhibitor (S)-1-chloro-3-[(p-tolylsulfonyl)amino][5,5,6,6-³H] heptanone (³H³TLCK) was prepared in an overall 41% radiochemical yield with a specific activity of 1.6 Ci/mmol in a 'one-pot' 3 step sequence begin