Synthesis of phosphorothioate analogs of phosphatidylinositol 3,4,5-trisphosphate

DOI: 10.1016/S0960-894X(97)00196-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1231 - 1234 (1997)

Update date:2022-07-29

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Authors:

Kubiak, Robert J.

Bruzik, Karol S.

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Article abstract of DOI:10.1016/S0960-894X(97)00196-0

Phosphorothioate analogs of phosphatidylinositol 3,4,5-trisphosphate have been synthesized using Me₃N-Me₃SiCl reagent in a critical exhaustive cleavage of O-benzyl phosphorothioate triester intermediates.

Full text of DOI:10.1016/S0960-894X(97)00196-0

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Product name:Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[(1R,2S,3S,4R,5R,6S)-3,4,5-tris-(bis-benzyloxy-thiophosphoryloxy)-2,6-bis-methoxymethoxy-cyclohexyloxy]-phosphoryloxy}-ethyl ester

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