Tetrahedron p. 8085 - 8104 (1997)
Update date:2022-09-26
Topics:
Faul, Margaret M.
Huff, Bret E.
Dunlap, Steven E.
Frank, Scott A.
Fritz, James E.
Kaldor, Stephen W.
LeTourneau, Michael E.
Staszak, Michael A.
Ward, Jeffrey A.
Werner, John A.
Winneroski, Leonard L.
The synthesis of 2',3'-dideoxy-3'-hydroxymethylcytidine 1 was accomplished using two different approaches. First, uridine and cytidine were used to prepare the key intermediate epoxides 15 and 31 which were opened with cyanide, deoxygenated by elimination to vinyl nitriles 17 and 36, and reduced by 1,4 hydride addition to the saturated nitriles 18 and 37. Secondly, a novel Rh-catalyzed hydroformylation reaction of 2',3'-didehydro-2',3'-dideoxycytidine 46 was used to prepare 1 in four steps. The attempted use of 2'-deoxyuridine and 2'-deoxycytidine to prepare 1 is also discussed.
View MoreContact:732.938.2777
Address:5012 Industrial Road Farmingdale, NJ 07727
Tianjin Hedong Red Cliff Chemical Reagent Factory
Contact:+86-022-84780548
Address:Li Ming Zhuang Gong Ye Yuan,Dongli District,Tianjin,China
Hangzhou TJM Chemical Trade Co., Ltd
Contact:86-571-88223276 86-13388481653
Address:2221#,Boyuexuan,1860# Binsheng Road,Binjiang District, Hangzhou CityZhejiang Province, 310051, P. R. China
Reliable Pharma Technology (Shanghai) Co., Ltd.
Contact:0086-21-67676847-8008
Address:Lane 1500, No.68, Xinfei Road, Songjiang District, Shanghai, 201611, P.R.China.
Shandong Ailitong New Material Co.,Ltd
Contact:+86-536-3226266
Address:zhongjia village, putong town , qingzhou city,Shandong Province,China
Doi:10.1016/S0040-4039(97)01315-4
(1997)Doi:10.1055/s-0037-1610110
(2018)Doi:10.1007/s00044-011-9574-8
(2012)Doi:10.1055/s-1997-930
(1997)Doi:10.1248/cpb.16.897
(1968)Doi:10.1039/C19680000688
(1968)
