Tetrahedron p. 8085 - 8104 (1997)
Update date:2022-09-26
Topics:
Faul, Margaret M.
Huff, Bret E.
Dunlap, Steven E.
Frank, Scott A.
Fritz, James E.
Kaldor, Stephen W.
LeTourneau, Michael E.
Staszak, Michael A.
Ward, Jeffrey A.
Werner, John A.
Winneroski, Leonard L.
The synthesis of 2',3'-dideoxy-3'-hydroxymethylcytidine 1 was accomplished using two different approaches. First, uridine and cytidine were used to prepare the key intermediate epoxides 15 and 31 which were opened with cyanide, deoxygenated by elimination to vinyl nitriles 17 and 36, and reduced by 1,4 hydride addition to the saturated nitriles 18 and 37. Secondly, a novel Rh-catalyzed hydroformylation reaction of 2',3'-didehydro-2',3'-dideoxycytidine 46 was used to prepare 1 in four steps. The attempted use of 2'-deoxyuridine and 2'-deoxycytidine to prepare 1 is also discussed.
View MoreShanghai Yingrui Biopharma Co., Ltd
Contact:021-3358 8661*8003
Address:shanghai
Quzhou Aokai Chemical Co., Ltd.
Contact:86-570-3032832
Address:NO.16 , Laodong Road,Quzhou City, Zhejiang Province,China
JIAXING SUNS INTERNATIONAL TRADE CO LTD
Contact:18367306858
Address:No.123,Huixin Avenue,Huimin Dist
Contact:+8618766299236
Address:ROOM808, BUILDING2,NO.230 SHEN ZHEN ROAD, LAOSHAN DISTRICT
Shanghai Hohance Chemical Co., ltd
Contact:13914753421
Address:Fl.5;Bld. 70, Lane 1500; Xinfei Road
Doi:10.1016/S0040-4039(97)01315-4
(1997)Doi:10.1055/s-0037-1610110
(2018)Doi:10.1007/s00044-011-9574-8
(2012)Doi:10.1055/s-1997-930
(1997)Doi:10.1248/cpb.16.897
(1968)Doi:10.1039/C19680000688
(1968)