Tetrahedron p. 8085 - 8104 (1997)
Update date:2022-09-26
Topics:
Faul, Margaret M.
Huff, Bret E.
Dunlap, Steven E.
Frank, Scott A.
Fritz, James E.
Kaldor, Stephen W.
LeTourneau, Michael E.
Staszak, Michael A.
Ward, Jeffrey A.
Werner, John A.
Winneroski, Leonard L.
The synthesis of 2',3'-dideoxy-3'-hydroxymethylcytidine 1 was accomplished using two different approaches. First, uridine and cytidine were used to prepare the key intermediate epoxides 15 and 31 which were opened with cyanide, deoxygenated by elimination to vinyl nitriles 17 and 36, and reduced by 1,4 hydride addition to the saturated nitriles 18 and 37. Secondly, a novel Rh-catalyzed hydroformylation reaction of 2',3'-didehydro-2',3'-dideoxycytidine 46 was used to prepare 1 in four steps. The attempted use of 2'-deoxyuridine and 2'-deoxycytidine to prepare 1 is also discussed.
View MoreJiangsu King Road New Materials Co., Ltd.
website:http://www.jskingroad.com
Contact:0519-85720726 0519-85720721 15006126856
Address:No.1,Weihua Road,Xinbei District,Changzhou City,Jiangsu Province
VanderArk International Limited
Contact:86-10-82437576
Address:Qing He
website:http://www.NEM.COM.CN
Contact:+86-393-4411771
Address:The west section of shengli Road,Puyang,Henan Province,China
Xuzhou Tianrun Chemical Co.,Ltd
website:http://www.tianrunchem.cn
Contact:86-516-83832636
Address:fuxing road
Hubei Xiangxi Chemical Industry Co.,Ltd
Contact:+86-710-3454830
Address:No.7, Daqing East Road, Xiangfan City, Hubei Province, China
Doi:10.1016/S0040-4039(97)01315-4
(1997)Doi:10.1055/s-0037-1610110
(2018)Doi:10.1007/s00044-011-9574-8
(2012)Doi:10.1055/s-1997-930
(1997)Doi:10.1248/cpb.16.897
(1968)Doi:10.1039/C19680000688
(1968)
