Synthesis of a series of polar, orthogonally protected, α,α-disubstituted amino acids

Article abstract of DOI:10.1016/S0040-4039(97)00822-8

The synthesis of four novel, 'cationic', α,α-disubstituted amino acids is described. The new amino acids use an orthogonal protection scheme making them suitable for incorporation via solid-phase peptide synthesis.