
Bioorganic and Medicinal Chemistry Letters p. 1235 - 1238 (1997)
Update date:2022-08-04
Topics:
Mihai, Cornelia
Mataka, Jan
Riddle, Suzette
Tsai, Ming-Daw
Bruzik, Karol S.
An optimized synthesis of enantiopure (2R)-1,2-dioctanoyloxy- and (2R)-1,2-dipalmitoyloxypropane-thiophospho-(1D-myo- inositol) is reported starting from R-glycidol and the readily available 1D-1-tert-butyldiphenylsilyl-myo-inositol. The key synthesis of the phosphothiolester bond is carried out by the phosphoramidite chemistry.
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