Carbohydrate Research p. 1 - 4 (1997)
Update date:2022-08-05
Topics:
Earle, Marion A.
Manku, Sukhdev
Hultin, Philip G.
Li, Hong
Palcic, Monica M.
A trimeric β-lactosyl cluster based on 2-nitro-2-(hydroxymethyl)propane- 1,3-diol was prepared using the trichloroacetimidate method. Kinetic studies showed that this cluster was an effective acceptor for rat-liver α-(2 → 3)-sialyltransferase. Its K(M) was comparable to those for monomeric lactose and N-acetyllactosamine accepters, and its V(MAX) was 1% of that measured for the LacNAc acceptor. Preparative-scale sialylation using this enzyme afforded a trimeric cluster of the ganglioside GM3 oligosaccharide in good yield. The NMR spectra of the trimeric GM3 analogue suggest that the oligosaccharide conformation is not significantly perturbed by this level of clustering.
View MoreShanghai PotentPharm Science and Technology Co.,Ltd
Contact:86-021-51969655
Address:Unit B, Building 18, No.300, Chuantu Rd,Pudong District, Shanghai 201202, China
Contact:+86-533-3112891
Address:zibo
Beijing Stable Chemcial Co.ltd
Contact:86-10-63785052
Address:A1301 Technological Edifice. No.4 FuFeng Road,FengTai District, Beijing. China
Contact:+86-535-8888888
Address:No.161 Haishi Rd.
Taizhou KEDE Chemical.Co.,Ltd.
Contact:86-576-84613060
Address:Jiangkou Chemical Zoon
Doi:10.1021/ol020158j
(2002)Doi:10.1039/jr9600004719
(1960)Doi:10.1021/acs.orglett.0c01053
(2020)Doi:10.1002/anie.202005151
(2020)Doi:10.1021/jo9706943
(1997)Doi:10.1248/cpb.31.1374
(1983)