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Novel dithiocarbamate carbapenems with anti-MRSA activity

DOI: 10.1016/S0960-894X(97)00272-2

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Bioorganic and Medicinal Chemistry Letters p. 1617 - 1622 (1997)

Update date:2022-08-03

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Authors:

Ohtake, NorikazuOhtake, Norikazu

Imamura, HideakiImamura, Hideaki

Kiyonaga, HideoKiyonaga, Hideo

Jona, HidekiJona, Hideki

Ogawa, MasayukiOgawa, Masayuki

Okada, ShigemitsuOkada, Shigemitsu

Shimizu, AyaShimizu, Aya

Moriya, MinoruMoriya, Minoru

Sato, HirokiSato, Hiroki

Tominaga, YushinTominaga, Yushin

Yamada, KojiYamada, Koji

Nakano, MasatoNakano, Masato

Ushijima, RyosukeUshijima, Ryosuke

Nakagawa, SusumuNakagawa, Susumu

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Article abstract of DOI:10.1016/S0960-894X(97)00272-2

A new series of carbapenems, in which disubstituted- aminothiocarbonylthio moiety, directly attached to the C-2 position, were prepared and evaluated for their antibacterial potency. These analogs showed potent activity against high-level MRSA. Among them

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Full text of DOI:10.1016/S0960-894X(97)00272-2

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Product name:(4R,5S,6S)-3-(4-Benzyl-piperazine-1-carbothioylsulfanyl)-6-((R)-1-hydroxy-ethyl)-4-methyl-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Cas No:192884-02-9

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