Bioorganic and Medicinal Chemistry Letters p. 1469 - 1474 (1997)
Update date:2022-07-30
Topics:
Yan, Yinfa
Liu, Min
Gong, Bing
DNA minor-groove binders consisting of two disubstituted benzene rings were prepared. Two ligands showed sequence selectivities higher than some of the best known minor-groove binders containing six-membered rings. Reversing the orientation of amide linkages in one ligand leads to another one with relaxed binding to AT sequences and greatly increased affinity toward GC sequences.
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