An alternative efficient synthesis of the C20-C25 building unit for calyculin A

Article abstract of DOI:10.1016/S0040-4020(97)00625-X

We have explored the efficient synthetic route to the C₂₀-C₂₅ building unit 3 for calyculin A (1) starting from the chiral γ-lactone 5 using the Wittig reaction, followed by hydroboration as the key steps.