Novel non-nucleosidic phosphoramidites for oligonucleotide modification and labeling

Article abstract of DOI:10.1016/S0960-894X(97)00278-3

A series of novel labeled phosphoramidites and CPG supports 1a-f with a new non-nucleosidic backbone based upon cyclohexyl-4-amino-1,1-dimethanol have been synthesized. These reagents have been used to label oligonucleotides with biotin and fluorescein at the 5'-, the 3'-, and internal positions.