Chemical and Pharmaceutical Bulletin p. 1146 - 1150 (1997)
Update date:2022-07-29
Topics:
Matsuoka, Hiroharu
Kato, Nobuaki
Ohi, Nobuhiro
Miyamoto, Katsuhito
Mihara, Masahiko
Takeda, Yasuhisa
The synthesis, biological profile and structure-activity relationship of various methotrexate (MTX) derivatives bearing an indoline ring are described. In particular, Nδ-(3-carboxyphenyl)-Nα-[1-[(2,4-diaminopteridin- 6-yl)methyl]indoline-5-ylcarbonyl]-L-glutamine (3d), compared to MTX; exhibited an enhanced anti-proliferative effect on human peripheral blood mononuclear cells obtained from healthy volunteers.
View MoreShandong Jiulong Hisince Pharmaceutical Co.,Ltd.
Contact:--
Address:Huadian Pioneer Park, Huadian Township, Qihe County, Dezhou City, Shandong, P.R.China
Contact:0086-27-83607103/83642615
Address:No.498, Jianshe Ave, Wuhan, China
Jinan Aery Pharmaceutical Co,.Ltd
Contact:+8653181263406
Address:1-1916,Building1 Fenghuang SOHO,Fenghuang Road,High-tech Zone,Jinan,Shandong
Quzhou Aokai Chemical Co., Ltd.
Contact:86-570-3032832
Address:NO.16 , Laodong Road,Quzhou City, Zhejiang Province,China
Taixing Joxin Bio-tec Co.,Ltd.
website:http://www.joxbio.com
Contact:86-523-87558858 87612088
Address:No.88, chengdong industrial park
Doi:10.1139/v67-412
(1967)Doi:10.1039/c4ce00315b
(2014)Doi:10.1002/cctc.201801606
(2018)Doi:10.1007/s10895-014-1362-7
(2014)Doi:10.1002/ejoc.201301825
(2014)Doi:10.3998/ark.5550190.p008.653
(2014)
