Antirheumatic agents. III. Novel methotrexate derivatives bearing an indoline ring and a modified ornithine or glutamie acid

DOI: 10.1248/cpb.45.1146

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1146 - 1150 (1997)

Update date:2022-07-29

Topics:

Authors:

Matsuoka, Hiroharu

Kato, Nobuaki

Ohi, Nobuhiro

Miyamoto, Katsuhito

Mihara, Masahiko

Takeda, Yasuhisa

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.45.1146

The synthesis, biological profile and structure-activity relationship of various methotrexate (MTX) derivatives bearing an indoline ring are described. In particular, Nδ-(3-carboxyphenyl)-Nα-[1-[(2,4-diaminopteridin- 6-yl)methyl]indoline-5-ylcarbonyl]-L-glutamine (3d), compared to MTX; exhibited an enhanced anti-proliferative effect on human peripheral blood mononuclear cells obtained from healthy volunteers.

Full text of DOI:10.1248/cpb.45.1146

NII-Electronic Library Service

Products guided by the article

Product name:methyl N^α-{1-[(2,4-diaminopteridin-6-yl)methyl]indolin-5-ylcarbonyl}-N^δ-succinyl-L-ornithinate

Cas No:194206-10-5

R&D Labs maybe for 194206-10-5

Tianjin Ingenochem Technology Co.,Ltd

Contact:+86-22-23677060

Address:Hitech Green Industry Park K2-9-602, Nankai district
shijiazhuang alkay chemicals co..ltd(expird)

Contact:86-311-67692035

Address:2601,juntang building,qiaodong district,shijiazhuang
Shanghai birch chemical technology co.,ltd

Contact:+86-21-54096810

Address:No.2588,Jungong Road,Shanghai,China
Hangzhou innopharma technology Co,.Ltd.(expird)

Contact:+86-13388601988

Address:Room845,lixin building, moganshan road, hangzhou, china
Hangzhou jls Flame Retardants Chemical Co.,Ltd

Contact:+86-571-87250387/87250386

Address:MOGANSHAN RODA 1418# SHANGCHENG INDUSTRIAL PARK

Relevant to this article

Doi:10.1139/v67-412
(1967)
Structural and photophysical study of copper iodide complex with P^N or P^N^P ligand

Doi:10.1039/c4ce00315b
(2014)
Click. Coordinate. Catalyze. Using CuAAC Click Ligands in Small-Molecule Model Chemistry of Tyrosinase

Doi:10.1002/cctc.201801606
(2018)
Synthesis and characterization of ultraviolet light-emitting organic acids

Doi:10.1007/s10895-014-1362-7
(2014)
Regioselective biomimetic oxidative cyclization strategy for the synthesis of aryldihydronaphthalene lignans

Doi:10.1002/ejoc.201301825
(2014)
Easy synthesis of new series of pteridine analogs: Di- and tetrahydropyrimido[ 4,5-d]pyrimidines via 5-pyrimidinecarbaldehydes

Doi:10.3998/ark.5550190.p008.653
(2014)

Article Doi