Chemical and Pharmaceutical Bulletin p. 1146 - 1150 (1997)
Update date:2022-07-29
Topics:
Matsuoka, Hiroharu
Kato, Nobuaki
Ohi, Nobuhiro
Miyamoto, Katsuhito
Mihara, Masahiko
Takeda, Yasuhisa
The synthesis, biological profile and structure-activity relationship of various methotrexate (MTX) derivatives bearing an indoline ring are described. In particular, Nδ-(3-carboxyphenyl)-Nα-[1-[(2,4-diaminopteridin- 6-yl)methyl]indoline-5-ylcarbonyl]-L-glutamine (3d), compared to MTX; exhibited an enhanced anti-proliferative effect on human peripheral blood mononuclear cells obtained from healthy volunteers.
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