Synthesis of polydeuterated benzothiazoles via supercritical deuteration of anilines

DOI: 10.1002/(SICI)1099-1344(199708)39:8<625::AID-JLCR15>3.0.CO;2-X

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 625 - 630 (1997)

Update date:2022-07-29

Topics:

Authors:

Junk, Thomas

Catallo, W. James

Civils, L. Dana

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1002/(SICI)1099-1344(199708)39:8<625::AID-JLCR15>3.0.CO;2-X

2-[²H]Benzothiazole, readily available according to the literature, was observed to undergo slow isotope exchange in water. This necessitated development of practical syntheses for benzothiazoles carrying deuterium labels in positions other than 2. [4,5,6,7-²H₄]Benzothiazole and 4-[²H₃]methyl[5,6,7-²H₃]benzothiazole were prepared in good yields from [²H₇]aniline and 2-[²H₉]toluidine, which were obtained by novel rapid isotope exchange in supercritical deuterium oxide.

Full text of DOI:10.1002/(SICI)1099-1344(199708)39:8<625::AID-JLCR15>3.0.CO;2-X

Products guided by the article

Product name:Benzothiazole-d4

Cas No:194423-51-3

R&D Labs maybe for 194423-51-3

Shijiazhuang Haotian Chemical Co., Ltd.

Contact:86-311-85044374

Address:293 Donggang Road
Hebei Think-Do Environment Co., Ltd

website:http://www.thinkdo-environment.com

Contact:0311-86510809-

Address:No 6, Shilian Middle Street, Circular Chemical Industry Park
Hunan Dinuo Pharmaceutical Co.,Ltd.

Contact:86-731-88280100*8561

Address:Bio-pharmaceutical industrial park, Liuyang, Hunan, China
Jintan Jinnuo Chemical Co., Ltd.

Contact:+86-519-80199901

Address:Room 1804, Building 1, Huacheng Business Plaza, Jintan, Jiangsu, China
Aminodiscovery Co.,Ltd.

Contact:+86-535-8888888

Address:No.161 Haishi Rd.

Relevant to this article

Synthesis and Properties of IrRe₂(μ-H)₂(CO)₉(η⁵-C ₉H₇)

Doi:10.1021/ic960990i
(1997)
Insertion of unsaturated hydrocarbons into the palladium-carbon bond of complexes (N?N)Pd(C(=N-2,6-Me₂Ph)Me)X (N?N = bpy, phen; X = Cl, Br, I, BF₄): A structural and mechanistic study

Doi:10.1021/om9701940
(1997)
Doi:10.1007/BF00908491
()
Doi:10.1021/jm00319a006
(1966)
The Importance of Hydrophobic-Hydrophilic Factors in Binding of Charged Substrates to Micelles: The Use of Extramicellar Probe Luminescence to Monitor Association of Cations to the Micelle

Doi:10.1021/ja00408a009
(1981)
Synthesis and evaluation of benzophenone-based photoaffinity labeling analogs of prenyl pyrophosphates containing stable amide linkages

Doi:10.1016/S0960-894X(97)00373-9
(1997)

Article Doi