Synthesis of polydeuterated benzothiazoles via supercritical deuteration of anilines

DOI: 10.1002/(SICI)1099-1344(199708)39:8<625::AID-JLCR15>3.0.CO;2-X

Source and publish data:

Journal of labelled compounds and radiopharmaceuticals p. 625 - 630 (1997)

Update date:2022-07-29

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Authors:

Junk, Thomas

Catallo, W. James

Civils, L. Dana

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Article abstract of DOI:10.1002/(SICI)1099-1344(199708)39:8<625::AID-JLCR15>3.0.CO;2-X

2-[²H]Benzothiazole, readily available according to the literature, was observed to undergo slow isotope exchange in water. This necessitated development of practical syntheses for benzothiazoles carrying deuterium labels in positions other than 2. [4,5,6,7-²H₄]Benzothiazole and 4-[²H₃]methyl[5,6,7-²H₃]benzothiazole were prepared in good yields from [²H₇]aniline and 2-[²H₉]toluidine, which were obtained by novel rapid isotope exchange in supercritical deuterium oxide.

Full text of DOI:10.1002/(SICI)1099-1344(199708)39:8<625::AID-JLCR15>3.0.CO;2-X

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