Bioorganic and Medicinal Chemistry Letters p. 1927 - 1930 (1997)
Update date:2022-07-29
Topics:
Reitz, Allen B.
McDonnell, Mark E.
Baxter, Ellen W.
Codd, Ellen E.
Wu, Wu-Nan
Several of the key metabolites of mazapertine, a novel antipsychotic agent, were prepared in order to firmly establish their chemical structure and to obtain samples for biological testing. Hydroxymazapertine 3 was synthesized via a multi-step procedure starting from 5-fluoro-2-nitrophenol (8). Alcohol 4 was originally proposed for one of the major metabolites, but the confirmed structure after synthesis was isomer 20.
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(1997)
