The synthesis and evaluation of the major metabolites of mazapertine

DOI: 10.1016/S0960-894X(97)00336-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1927 - 1930 (1997)

Update date:2022-07-29

Topics:

Authors:

Reitz, Allen B.

McDonnell, Mark E.

Baxter, Ellen W.

Codd, Ellen E.

Wu, Wu-Nan

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)00336-3

Several of the key metabolites of mazapertine, a novel antipsychotic agent, were prepared in order to firmly establish their chemical structure and to obtain samples for biological testing. Hydroxymazapertine 3 was synthesized via a multi-step procedure starting from 5-fluoro-2-nitrophenol (8). Alcohol 4 was originally proposed for one of the major metabolites, but the confirmed structure after synthesis was isomer 20.

Full text of DOI:10.1016/S0960-894X(97)00336-3

Products guided by the article

Product name:Benzene, 2-(1-methylethoxy)-1-nitro-4-(phenylmethoxy)-

Cas No:194737-97-8

R&D Labs maybe for 194737-97-8

Shanghai Sunwise Chemical Co., Ltd

website:http://www.sunwisechem.com

Contact:86-021-33883180

Address:Room 10E, Building G, Westlink Center, No. 2337 Gudai Road, Minhang District, Shanghai, China PC: 201100
Chengdu Sino-Strong Pharmaceutical Co.,Ltd.

website:http://www.sino-strong.com.cn

Contact:+86-28-82666753

Address:459 West haike road,Cross-straits technological industry park, Wenjiang district,Chengdu, P.R.China
Guangzhou Chemical Reagent Factory

Contact:+86-20-8435 9820 or 8435 7345

Address:Southern Guangzhou, Guangdong, China
CHEM PLUS

Contact:0027-717-456976

Address:2ND FLOOR, 325 VAUSE ROAD, OVERPORT, 4001, SOUTH AFRICA
Shreeji pharma international

Contact:0091-265-2313036

Address:311, ATLANTIS HEIGHTS SARABHAI MAIN ROAD,VADIWADI ,VADODARA

Relevant to this article

C-H bond cleavage in thiophenes by [P(CH₂CH₂PPh₂)₃Ru]. UV flash kinetic spectroscopy discloses the ruthenium-thiophene adduct which precedes C-H insertion

Doi:10.1021/om9703898
(1997)
First enantioselective addition of diethylzinc and dimethylzinc to prostereogenic ketones catalysed by camphorsulfonamide-titanium alkoxide derivatives

Doi:10.1016/S0040-4020(98)00236-1
(1998)
Mechanism and scope of salen bifunctional catalysts in asymmetric aldehyde and α-ketoester alkylation

Doi:10.1016/j.tet.2005.03.117
(2005)
Total enantiotopic discrimination between carbon atoms of a double bond in the reaction of diolates with meso-Bis(phenylsulfonyl)alkenes - Synthesis of enantiopure ketones

Doi:10.1002/anie.199715041
(1997)
Epoxidation of (E,E)-cinnamylideneacetophenones with hydrogen peroxide and iodosylbenzene with salen-Mn^III as the catalyst

Doi:10.1002/ejoc.200700123
(2007)
Replacement of a cyclometalated terdentate diamino ligand by a phosphorus analogue. Isolation and crystallographic characterization of an intermediate in aryl C-H bond activation in models of dendrimer-bound organometallic catalysts

Doi:10.1021/ja9710060
(1997)

Article Doi