Total enantiotopic discrimination between carbon atoms of a double bond in the reaction of diolates with meso-Bis(phenylsulfonyl)alkenes - Synthesis of enantiopure ketones

Article abstract of DOI:10.1002/anie.199715041

Desymmetrization of bis(phenylsulfonyl)alkenes 1 provides the desired enantiomer of polycyclic ketones rapidly, in high yields and enantiopure 1 is also readily available in multigram quantities.