Dimeric aminoglycosides: Design, synthesis and RNA binding

DOI: 10.1016/S0960-894X(97)00339-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1951 - 1956 (1997)

Update date:2022-08-04

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Authors:

Wang, Hai

Tor, Yitzhak

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Article abstract of DOI:10.1016/S0960-894X(97)00339-9

The design and synthesis of symmetrical and non-symmetrical dimeric aminoglycosides derived from kanamycin A, tobramycin, and neomycin B are described. The covalently-linked dimeric aminoglycosides show enhanced activity as ribozyme inhibitors when compared to their natural counterparts.

Full text of DOI:10.1016/S0960-894X(97)00339-9

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