Alkylating Angiotensin II Analogues: Synthesis, Analysis, and Biological Activity of Angiotensin II Analogues Containing the Nitrogen Mustard Melphalan in Position 8

DOI: 10.1021/jm00143a009

Source and publish data:

Journal of Medicinal Chemistry p. 1304 - 1310 (1981)

Update date:2022-08-04

Topics: Synthesis ANGIOTENSIN II Analogues Analysis Biological Activity

Authors:

Hsieh, Kun-hwa

Marshall, Garland R.

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Article abstract of DOI:10.1021/jm00143a009

Melphalan derivatives suitable for peptide synthesis, i.e., Boc-Mel and Mel-OBzl*HCl, have been prepared, and the integrity of their nitrogen mustard alkylating groups was examined by NMR, Volhard chlorine analysis, and colorimetric assay with 4-(p-nitrob

Full text of DOI:10.1021/jm00143a009

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