Alkylating Angiotensin II Analogues: Synthesis, Analysis, and Biological Activity of Angiotensin II Analogues Containing the Nitrogen Mustard Melphalan in Position 8

Article abstract of DOI:10.1021/jm00143a009

Melphalan derivatives suitable for peptide synthesis, i.e., Boc-Mel and Mel-OBzl*HCl, have been prepared, and the integrity of their nitrogen mustard alkylating groups was examined by NMR, Volhard chlorine analysis, and colorimetric assay with 4-(p-nitrob