Tetrahedron Letters p. 5785 - 5788 (1997)
Update date:2022-08-04
Topics:
Chen, Yaun-Shek
Lawton, Richard G.
A simple, efficient synthesis of 2-(1,2-dithiolan-3-yl)acetic acid from Meldrum's acid, acrolein and thioacetic acid is described. The isopropyldene 2,4-bis(acetylthio)butane-1,1-dicarboxyl formed in the three-component, single container process, can be methanolized to the corresponding dimethyl ester and then hydrolyzed, oxidized to the disulfide and decarboxylated to 2-(1,2-dithiolan-3-yl)acetic acid. The acid can be converted by conventional reagents into a variety of amide derivatives.
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