On a baker's yeast-mediated approach to verapamil's optically active intermediates

DOI: 10.1016/S0040-4020(97)00667-4

Source and publish data:

Tetrahedron p. 10555 - 10564 (1997)

Update date:2022-08-04

Topics:

Authors:

Brenna, Elisabetta

Caraccia, Nicola

Fogliato, Giovanni

Fronza, Giovanni

Fuganti, Claudio

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Article abstract of DOI:10.1016/S0040-4020(97)00667-4

Racemic hydroxylactones 11a and 11b were converted through the key aldehyde intermediate 21 into the C₆-C₄ acid 22, showing all the necessary functionalities for the subsequent transformation into verapamil 1. Baker's yeast reduction

Full text of DOI:10.1016/S0040-4020(97)00667-4

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