New analogs of the pyripyropene family of ACAT inhibitors via α-pyrone fragmentation and γ-acylation/cyclization

DOI: 10.1246/cl.1997.935

Source and publish data:

Chemistry Letters p. 935 - 936 (1997)

Update date:2022-08-04

Topics:

Authors:

Obata, Rika

Sunazuka, Toshiaki

Tian, Zhiming

Tomoda, Hiroshi

Harigaya, Yoshihiro

Omura, Satoshi

Smith III, Amos B.

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Article abstract of DOI:10.1246/cl.1997.935

The pyridine moiety of pyripyropene A was replaced with other aromatic and heteroaromatic substituents via α-pyrone degradation followed by dienolate γ-acylation and in situ cyclization.

Full text of DOI:10.1246/cl.1997.935

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