A convergent synthesis of (+)-pancratistatin based on intramolecular electrophilic aromatic substitution

Article abstract of DOI:10.1016/S0040-4020(97)00373-6

A convergent formal synthesis of (+)-pancratistatin (1) is reported. Specifically, an optically active adduct of piperonyl bromide and acetonated conduritol A was converted to a late-stage intermediate from the Danishefsky-Lee synthesis of 1. The carbon s