Asymmetric synthesis of (R)- and (S)-methyl (2-methoxycarbonylcyclopent-2-enyl)acetate and (R)- and (S)-2-(2-hydroxymethyl-cyclopent-2-enyl)ethanol

Article abstract of DOI:10.1016/S0957-4166(97)00340-6

(R)- and (S)-Methyl (2-methoxycarbonylcyclopent-2-enyl)aceta 1 and (R)-and (S)-2-(2-hydroxymethyl-cyclopent-2-enyl) ethanol 2 have been obtained from dimethyl (E,E)-octa-2,6-diendioate 3 by a diastereoselective tandem conjugate addition protocol, from (R)- and (S)-lithium (α-methylbenzyl)benzylamide 4 respectively.