Galactosylation with β-Galactosidase from bovine testes employing modified acceptor substrates

DOI: 10.1016/S0968-0896(97)00071-0

Source and publish data:

Bioorganic and Medicinal Chemistry p. 1285 - 1291 (1997)

Update date:2022-07-29

Topics:

Authors:

Gambert, Ulrike

Gonzalez Lio, Raul

Farkas, Erzsebet

Thiem, Joachim

Verez Bencomo, Vicente

Liptak, Andras

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Article abstract of DOI:10.1016/S0968-0896(97)00071-0

In this study β1-3 linked analogues of the T-antigen determinant were synthesized in preparative scale by transgalactosylation using β-galactosidase from bovine testes to give synthetic antigens. Accepters with modifications of the sugar residue such as α-glycosylated spacers, as well as GlcNAc-αOR- and 2dGal-αOR-substrates opened further possibilities for galactosylation.

Full text of DOI:10.1016/S0968-0896(97)00071-0

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