Bioorganic and Medicinal Chemistry p. 1285 - 1291 (1997)
Update date:2022-07-29
Topics:
Gambert, Ulrike
Gonzalez Lio, Raul
Farkas, Erzsebet
Thiem, Joachim
Verez Bencomo, Vicente
Liptak, Andras
In this study β1-3 linked analogues of the T-antigen determinant were synthesized in preparative scale by transgalactosylation using β-galactosidase from bovine testes to give synthetic antigens. Accepters with modifications of the sugar residue such as α-glycosylated spacers, as well as GlcNAc-αOR- and 2dGal-αOR-substrates opened further possibilities for galactosylation.
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