Synthesis of an N-Alkyl Derivative of 2′-Deoxywoguanosine

Article abstract of DOI:10.1055/s-1997-952

3′,5′-O-bis-tert-butyldimethylsilyl-2′-deoxyguanosine is converted in two steps to 3′,5′-O-tert-butyldimethylsilyl-6-O-aryl-2′-deoxyxanthosine. This compound is used to make a 2′-deoxyisoguanosine analog with a functionalized side chain.