Bioorganic and Medicinal Chemistry p. 1293 - 1299 (1997)
Update date:2022-08-04
Topics:
Swahn, Britt-Marie
Edvinsson, Karin M.
Kallin, Elisabet
Larsson, Ulf
Berge, Odd-Geir
Molin, Hakan
Pelcman, Benjamin
Claesson, Alf
(2R,3S,1'R)-3-(1-Hydroxy-2-phosphonoethyl)-2-piperidinecarboxylic acid 1 has been synthesized by two different methods. The NMDA receptor binding affinities (K(i) values) are 74 nM for compound 1, and 64 nM for the corresponding ketone 2. The analgesic effects were evaluated using the mouse hot-plate test and the mouse formalin model. The ED50 values for the racemates of compounds 1 and 2, using the mouse hotplate and intrathecal injection, were 0.53 and 0.51 nmol, respectively.
View MoreMollt Biochem Co., Ltd(expird)
Contact:+86-21-38682181
Address:shanghai ,china
Shandong Xinke Petrochemical Co., Ltd.
Contact:+86-546-7277016
Address:Gudao Industrial Park, Hekou District, Dongying, Shandong Province, China
Jiangsu Zhenfang Chemical CO.,LTD.(Suzhou Zhenfang Chemical Factory)
Contact:+86-512-69598882
Address:Room1201, Jiayuan Road No.1018, Xiangcheng District, Suzhou, China
Nanjing Qirui Material Co., Ltd.
Contact:+86-25-52320053
Address:F4-5, #17 Building, Chuang Yi Yuan, No.6 Guanghua East Street, Nanjing, 210007 P.R.China
A.M FOOD CHEMICAL CO., LIMITED
Contact:86-531-87100375
Address:20Floor，Bblock，1Building，pharma-valley，Jinan，China
Doi:10.3987/com-97-7865
(1997)Doi:10.1021/jo01050a518
(1962)Doi:10.1016/j.bmcl.2006.02.056
(2006)Doi:10.1002/cbic.201800148
(2018)Doi:10.1080/07328309708005741
(1997)Doi:10.1016/S0277-5387(97)00221-0
(1997)
