A convenient and efficient synthesis of sialyl Lewis X.

DOI: 10.1271/bbb.62.590

Source and publish data:

Bioscience, Biotechnology and Biochemistry p. 590 - 592 (1998)

Update date:2022-08-03

Topics:

Authors:

Baba Baba

Iwata Iwata

Hamajima

Ikami Ikami

Ishida Ishida

Hasegawa

Kiso Kiso

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Article abstract of DOI:10.1271/bbb.62.590

A convenient synthesis of the sialyl Lewis X (sLe(x)) tetrasaccharide, NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc (8), as a carbohydrate ligand for selectins is described. The key step is the reaction between NeuAc alpha 2-3GalSMe (5) as a glycosyl donor and the suitably protected Fuc alpha 1-3GlcNAc derivative (4) as the glycosyl acceptor by using dimethyl(methylthio)sulfonium triflate (DMTST) as the promoter.

Full text of DOI:10.1271/bbb.62.590

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