Derivatives of (R)-2-amino-5-methoxytetralin: Antagonists and Inverse Agonists at the Dopamine D2A Receptor

Article abstract of DOI:10.1016/S0960-894X(99)00345-5

A series of N-arylmethyl substituted (R)-5-methoxy-2-(propylamino)tetralins has been prepared and evaluated for affinity and efficacy at dopamine (DA) D_2A receptors. The novel compounds appeared to be antagonists or inverse agonists. (R)-2-<(Be