Intramolecular cycloaddition of nitrones with sulfur-substituted dienes and its synthetic applications

Article abstract of DOI:10.1016/S0040-4039(97)01037-X

A series of sulfur-substituted dienyl nitrones were conviently prepared from the 3-sulfolene precursors. Intramolecular 1,3-dipolar cycloaddition reactions gave the fused bicyclic isoxazolidines. The regio- and stereochemical outcome of these reactions as well as the synthetic applications have been explored.