(+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metbotropic glutamate mGluR1 receptors

DOI: 10.1016/S0960-894X(97)10071-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2777 - 2780 (1997)

Update date:2022-08-03

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Authors:

Clark, Barry P.

Baker, S. Richard

Goldsworthy, John

Harris, John R.

Kingston, Ann E.

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Article abstract of DOI:10.1016/S0960-894X(97)10071-3

The synthesis of three novel 4-carboxyphenylglycine (LY367385) selectively antagoises metabotropic glutamate mGluR1 receptors. Resolution of compound 1 showed that the activity resided in the (+)-isomer LY367385.

Full text of DOI:10.1016/S0960-894X(97)10071-3

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