The synthesis of the sixteen possible 2'-O-methyl MMI dimer phosphoramidites: Building blocks for the synthesis of novel antisense oligonucleotides

Article abstract of DOI:10.1080/07328319708006118

The synthesis of Methylene(methylimino) or MMI linked nucleoside dimers in all sixteen possible configurations has been accomplished via a reductive coupling of a nncleosidic aldehyde with an hydroxylamine. This has allowed us to prepare all of the necessary 2'-O-methyl MMI dimer building blocks necessary for use in an antisense motif.

Full text of DOI:10.1080/07328319708006118

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The Synthesis of the Sixteen
Possible 2′-O-Methyl MMI Dimer
Phosphoramidites: Building Blocks
for the Synthesis of Novel Antisense
Oligonucleotides
Eric E. Swayze a , Balkrishen Bhat a , Didier Peoc'h a & Yogesh S.
Sanghvi a
a Isis Pharmaceuticals , 2292 Faraday Av., Carlsbad, CA, 92008
Published online: 16 Aug 2006.
To cite this article: Eric E. Swayze , Balkrishen Bhat , Didier Peoc'h & Yogesh S. Sanghvi (1997)
The Synthesis of the Sixteen Possible 2′-O-Methyl MMI Dimer Phosphoramidites: Building Blocks for
the Synthesis of Novel Antisense Oligonucleotides, Nucleosides and Nucleotides, 16:7-9, 971-972,
DOI: 10.1080/07328319708006118
To link to this article: http://dx.doi.org/10.1080/07328319708006118
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