Preparation of benzene, furan, and thiophene analogs of duocarmycin SA employing a newly-devised phenol-forming reaction

DOI: 10.1248/cpb.48.1558

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1558 - 1566 (2000)

Update date:2022-08-05

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Authors:

Muratake

Hayakawa

Natsume Natsume

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Article abstract of DOI:10.1248/cpb.48.1558

Five A-ring analogs of duocarmycin SA 9a - e were synthesized in racemic form modifying our second synthetic route toward duocarmycin SA. The problem encountered at the crucial phenol forming step to secure 17a, b from 16a, b under the conventionally used

Full text of DOI:10.1248/cpb.48.1558

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