The development of strategies for construction of the aziridine core of the antitumor agents azinomycins A and B

DOI: 10.1016/S0040-4020(97)01017-X

Source and publish data:

Tetrahedron p. 16313 - 16326 (1997)

Update date:2022-08-04

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Authors:

Coleman, Robert S.

Carpenter, Andrew J.

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Article abstract of DOI:10.1016/S0040-4020(97)01017-X

The synthesis of the C6-C13 aziridino[1,2a]pyrrolidine core substructure of the antitumor agents azinomycins A (1a) and B (1b) is described. Key synthetic steps included Wadsworth-Horner-Emmons olefination for formation of the C7-C8 double bond, an E-sele

Full text of DOI:10.1016/S0040-4020(97)01017-X

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