European Journal of Medicinal Chemistry p. 823 - 831 (1997)
Update date:2022-08-05
Topics:
Gibson
Binyamin
Haj
Ringel
Ramu
Katzhendler
A series of complexes PtAm2L [where Am2 = (NH3)2, ethylenediamine(en), 1,2-diaminocyclohexane (DACH) or (NH3)(c-C6H11NH2) and where L is a bidentate 1,1-dicarboxylate ligand tethered to 1- aminoanthraquinone by various spacers] was prepared and screened in vitro against P388 leukemia cells. The free ligands displayed moderate activity and the corresponding platinum complexes were tenfold more active. The nature of the linker chain does not seem to affect the potency of the complexes. The potency depends on the nature of the inert amine ligand [NH3 > DACH > en]. The low aqueous solubility of these complexes prevented any in vivo studies and the preparation of water soluble analogs is currently under way.
View MoreContact:+86-731-84427351
Address:154 JIANXIANG SOUTH ROAD
SHANGHAI ARCADIA BIOTECHNOLOGY LTD.
Contact:+86-21-61353236
Address:SUITE 901, BUILDING WENSLI, 1378 LU JIA BANG RD, SHANGAHI 200011, P.R.CHINA
Xi'an Costrong Pharmaceutical Co., Ltd.
Contact:029- 68576496
Address:Room 2004,Shuibao Building,No.190,South Erhuan Rd, Yanta District,Xi'an,Shaan Xi,China
Shenyang Xingzhenghe Chemical Co., Ltd.
Contact:024-23509232
Address:No. 33, Naner Road, Heping Dist.
Changsha Goomoo Chemical Technology Co.Ltd
Contact:+86-731-82197655
Address:No.649,Chezhan Rd.(N),Changsha,Hunan,China
Doi:10.1246/bcsj.16.397
(1941)Doi:10.1021/acs.orglett.5b00699
(2015)Doi:10.1021/jo971692l
(1998)Doi:10.1016/S0040-4039(97)10559-7
(1998)Doi:10.1021/ja01227a019
(1945)Doi:10.1021/jf60168a019
(1970)