Tetrahedron Letters p. 8911 - 8914 (1997)
Update date:2022-08-04
Topics:
Paterson, Ian
Wallace, Debra J.
Gibson, Karl R.
The C16-C28 ketone 3, containing the CD-spiroacetal of spongistatin 1 (1), was prepared in 17 steps from aldehyde 9. Both thermodynamic and kinetic conditions were explored for controlling the CD-acetal configuration.
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