Diastereoselective synthesis of trans-2-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropanecarboxylic acids: Key intermediates for the preparation of potent and chiral histamine H3 receptor agents

DOI: 10.1016/S0960-894X(97)10137-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3017 - 3022 (1997)

Update date:2022-07-29

Topics:

Authors:

Khan, M. Amin

Yates, Stephen L.

Tedford, Clark E.

Kirschbaum, Kristin

Phillips, James G.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)10137-8

Procedures for the preparation of both enantiomers of trans-2-(1-triphenylmethyl-1H-imidazol-4-yl)-cyclopropanecarboxylic acid are described. The key step in the synthesis is a 3:1 diastereoselective cyclopropanation of (5R)-trans-4-aza-10,10-dimethyl-3-t

Full text of DOI:10.1016/S0960-894X(97)10137-8

Products guided by the article

Product name:(E)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(1-trityl-1H-imidazol-4-yl)-propenone

Cas No:201669-68-3

R&D Labs maybe for 201669-68-3

Shandong Dayi Chemical Co., Ltd.

website:http://www.dayi.com.cn

Contact:+86- 535-7388728. 15306386031

Address:No 1 Danya west road, Laiyang City, Shandong province
Hangzhou Chemfar Ltd.

Contact:+86-571-87859231, 87859237, 87859239

Address:1606,Huarong Times Mansion, No.3880 Jiangnan Avenue, Binjiang District, Hangzhou, China, 310053
lianyungang jinkang pharmaceutical technology co., ltd.

Contact:008651885445517

Address:Jinshan industrial park, Ganyu county, Lianyungang, Jiangsu Province, 222115, China
Taizhou Chemedir Biopharm-tech Co., Ltd

Contact:+86 523 86200218

Address:G09, No. 1 Avenue China Medical City, Taizhou,Jiangsu, China
Tianjin Crest Pharmaceutical R&D Co., Ltd. （Tianjin Yao Technology Development Co., Ltd.）(expird)

Contact:+86-22-66211386

Address:Building B5-405, No, 80 4th Avenue, TEDA, Tianjin, China P.R. 300457

Relevant to this article

Transition metal complexes of nitroxide radicals, palladium, platinum, pentamethyleyclopentadienyl rhodium and iridium complexes, and α-aminocarboxylate complexes with derivatives of 2,5-dihydroimidazole-1-oxyls

Doi:10.1515/znb-1998-0118
(1998)
Doi:10.1021/ja01019a024
(1968)
A new efficient preparation of polyfunctional phosphines using zinc organometallics

Doi:10.1016/0040-4039(95)00813-R
(1995)
Rh(iii)-Catalyzed diastereoselective transfer hydrogenation: An efficient entry to key intermediates of HIV protease inhibitors

Doi:10.1039/c9cc09793g
(2020)
Asymmetric reduction of (Z)-α,β-dehydrotryptophanyl-containing biological peptides with sulfur functionality. Influence of substrate on stereoselectivity

Doi:10.1016/S0040-4020(00)00329-X
(2000)
Novel acylation catalysts in peptide synthesis: Derivatives of N-hydroxytriazoles and N-hydroxytetrazoles

Doi:10.1039/a707313e
(1998)

Article Doi