Diastereoselective synthesis of trans-2-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropanecarboxylic acids: Key intermediates for the preparation of potent and chiral histamine H3 receptor agents

DOI: 10.1016/S0960-894X(97)10137-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3017 - 3022 (1997)

Update date:2022-07-29

Topics:

Authors:

Khan, M. Amin

Yates, Stephen L.

Tedford, Clark E.

Kirschbaum, Kristin

Phillips, James G.

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Article abstract of DOI:10.1016/S0960-894X(97)10137-8

Procedures for the preparation of both enantiomers of trans-2-(1-triphenylmethyl-1H-imidazol-4-yl)-cyclopropanecarboxylic acid are described. The key step in the synthesis is a 3:1 diastereoselective cyclopropanation of (5R)-trans-4-aza-10,10-dimethyl-3-t

Full text of DOI:10.1016/S0960-894X(97)10137-8

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Product name:(E)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(1-trityl-1H-imidazol-4-yl)-propenone

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