
Tetrahedron Letters p. 8591 - 8594 (1994)
Update date:2022-09-26
Topics:
Kabbara, Jazid
Flemming, Steffen
Nickisch, Klaus
Neh, Harribert
Westermann, Juergen
The effect of silanes as additives in the copper-catalyzed conjugate alkylation of enones by various organoaluminium reagents was investigated. TMSCl led to significant lower amounts of CuBr catalyst needed in the reaction of trimethylaluminium with enones, but was unsuccessful in the case of organoaluminium compounds of the formula Me2AlY (Y = Cl, OR). Me2AlOEt turned out to be a useful reagent for methylation without support of additives.
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