The role of silanes on the copper-catalyzed conjugate alkylation of enones by organoaluminium reagents

Article abstract of DOI:10.1016/S0040-4039(00)78444-9

The effect of silanes as additives in the copper-catalyzed conjugate alkylation of enones by various organoaluminium reagents was investigated. TMSCl led to significant lower amounts of CuBr catalyst needed in the reaction of trimethylaluminium with enones, but was unsuccessful in the case of organoaluminium compounds of the formula Me₂AlY (Y = Cl, OR). Me₂AlOEt turned out to be a useful reagent for methylation without support of additives.