Tetrahedron Letters p. 209 - 212 (1998)
Update date:2022-08-04
Topics:
Bijoy, Panicker
Avery, Mitchell A.
Enantioselective syntheses of a protected C7-C15 fragment of epothilone A is reported in ten manipulations in good overall yield. An alkynyl-aluminium induced opening of a chiral epoxide followed by recording of functionally furnished the iodide 18. Chain elongation with N-propionyl-1S-(-)-2,10-camphorsultam 19 afforded the elaborated acylsultam 20 which was reduced and reoxidized to furnish a protected chiral aldehyde 6 suitable for aldol condensation, representing the C7-C15 portion of epothilone A.
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