Synthesis and some properties of 4-alkyl-5-cyano-6-mercapto-3,4-dihydropyridin-2(1H)-ones

Article abstract of DOI:10.1007/BF02503785

Condensation of propionic (or acetic) aldehyde, cyanothioacetamide, Meldrum's acid, and N-methylmorpholine occurs via the intermediate formation of the corresponding Michael adducts and yields 4-alkyl-5-cyano-6-mercapto-3,4-dihydropyridin-2(1H)-ones. The oxidation of the reaction products with DMSO and their alkylation were studied.