Lanthanide Ion as a Catalyst for Internucleotide Bond Formation

Article abstract of DOI:10.1246/bcsj.69.1701

The lanthanide ion-catalyzed oligomerization of adenosine 5′-(l-imidazolylphosphate) was performed to yield short-chained oligoriboadenylates. The effect of lanthanide ions on the synthesis of oligoriboadenylates increased nearly in the order of the atomic number: None 3+?La³⁺?Ce³⁺?Pr ³⁺?Sm³⁺?Eu³⁺?Gd³⁺ 3+ ?Dy³⁺?Ho³⁺< Er³⁺ 3+ < Lu³⁺. The total yield of the oligoriboadenylates was 49% when Lu³⁺ was used as a catalyst. The linkage in the resulting oligoribadenylate was mainly 2′-5′.