Synthesis and biological activity of a new anti-factor Xa pentasaccharide with a C-interglycosidic bond

DOI: 10.1016/S0960-894X(97)00252-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1507 - 1510 (1997)

Update date:2022-08-03

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Authors:

Helmboldt, Arnim

Petitou, Maurice

Mallet, Jean-Maurice

Herault, Jean-Pascal

Lormeau, Jean-Claude

Driguez, Pierre Alexandre

Herbert, Jean-Marc

Sinay, Pierre

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Article abstract of DOI:10.1016/S0960-894X(97)00252-7

A mixed synthetic C, O-pentasaccharide 17 has been synthesized and shown to display an anti-factor Xa activity similar to that of the corresponding O-pentasaccharide 18. 17 represents the first example of a synthetic C-oligosaccharidic mimetic eliciting a significant biological response.

Full text of DOI:10.1016/S0960-894X(97)00252-7

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