Synthesis of spiroheterocyclic systems from barbituric acids and N,N-disubstituted o-aminobenzaldehydes

Article abstract of DOI:10.1007/s11178-005-0263-2

Reactions of barbituric, 1,3-dimethylbarbituric, and 2-thiobarbituric acids with 2-(1-pyrrolidinyl)benzaldehyde, its 6- and 7-membered homologs, and 4-phenylpiperazine and morpholine analogs lead to formation of fused systems with a spirocyclic 2,4,6-trio