A new synthetic method for the preparation of nucleoside phosphoramidate analogues with the nitrogen atom in bridging positions of the phosphoramidate linkage

Article abstract of DOI:10.1016/S0040-4039(97)10734-1

An efficient method for the preparation of nucleoside P3' → N5' and N3' → P5' phosphoramidates and their thio analogues results from generation of a pyridine adduct of a nucleoside metaphosphate or its analogue from a nucleoside H-phosphonate, nucleoside H-phosphonothioate or nucleoside H-phosphonodithioate monoester followed by its reaction with 5'- or 3'-aminonucleoside.