Bioorganic and medicinal chemistry p. 2165 - 2172 (1997)
Update date:2022-08-02
Topics:
Boes, Michael
Canesso, Rolf
Inoue-Ohga, Noriko
Nakano, Atsuko
Takehana, Yuki
Sleight, Andrew J.
O-Methylasparvenone (1) and asparvenone (2) were isolated from an Aspergillus parvulus Smith broth in a microbial screening for 5-HT2C ligands and found to be 5-HT2C antagonists.They represent the first nitrogen-free serotonin ligands.The absolute configuration of 1 was determined to be S by X-ray analysis of the corresponding Mosher-ester.A short and efficient synthesis of rac-1 was developed.This protocol was applied to the synthesis of derivatives of 1 and a structure-affinity relationship was established.
View MoreShandong Wanda Organosilicon New Material Co., Ltd
Contact:+86-21-54177116;54302881
Address:R1318 Greenland No. 3 Lane 58 Xinjian East Rd., Minhang
Jiangxi Dongxu Chemical Science & Technology Co.,Ltd
Contact:+86-791-86899381
Address:Nanchang, Jiangxi, China
Hangzhou Neway Chemicals Co., Ltd.
Contact:+86-571-85095566
Address:Room 803, Qinglian Bldg, No 139 Qingchun Road, Hangzhou, Zhejiang China
Guangzhou Reachin Chemical Co., Ltd
Contact:+86-20-37087379 ext.604
Address:A122C-1, Tianyuan Plaza, 401 Tianyuan Rd., Tianhe, Guangzhou, China
Anhui Redstar Pharmaceutical Corp., Ltd
Contact:+86-563-5120837
Address:Jingxian Industrial Development Zone, Anhui , China
Doi:10.1002/anie.200504468
(2006)Doi:10.1016/S0040-4039(98)00085-9
(1998)Doi:10.1021/ic50005a039
(1963)Doi:10.1002/(SICI)1099-0682(199803)1998:3<375::AID-EJIC375>3.0.CO;2-9
(1998)Doi:10.1021/jacs.8b08100
(2018)Doi:10.1016/S0040-4020(02)00465-9
(2002)
