Bioorganic and Medicinal Chemistry Letters p. 65 - 70 (1998)
Update date:2022-09-26
Topics:
Auberson, Yves P.
Bischoff, Serge
Moretti, Robert
Schmutz, Markus
Veenstra, Siem J.
A series of 5-aminomethylquinoxaline-2,3-diones have been identified as potent and selective AMPA antagonists. Some of these compounds are also active at the glycine-binding site of the NMDA receptors. A number of these novel, water-soluble quinoxaline-2,3-dione derivatives display protective effects in the electroshock-induced convulsion model in mice.
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