5-aminomethylquinoxaline-2,3-diones. Part 1: A novel class of ampa receptor antagonists.

Article abstract of DOI:10.1016/S0960-894X(97)10186-X

A series of 5-aminomethylquinoxaline-2,3-diones have been identified as potent and selective AMPA antagonists. Some of these compounds are also active at the glycine-binding site of the NMDA receptors. A number of these novel, water-soluble quinoxaline-2,3-dione derivatives display protective effects in the electroshock-induced convulsion model in mice.