Synthesis and antitumor activity of 4-phenyl-1-arylsulfonyl imidazolidinones

DOI: 10.1016/S0960-894X(98)00261-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1547 - 1550 (1998)

Update date:2022-07-29

Topics:

Authors:

Jung, Sang-Hun

Lee, Hui-Soon

Song, Jae-Shin

Kim, Hwan-Mook

Han, Sang-Bae

Lee, Chang-Woo

Lee, Moonsun

Choi, Dong-Rack

Lee, Jung-Ah

Chung, Yong-Ho

Yoon, Sung-June

Moon, Eun-Yi

Hwang, Hyun-Sook

Seong, Seung-Kyoo

Lee, Dug-Keun

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00261-3

Novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones 3 synthesized show highly potent and broad cytotoxicities. Among them compound 3b (DW2143) exhibits much more potent cytotoxicities than doxorubicin and highly effective antitumor activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.

Full text of DOI:10.1016/S0960-894X(98)00261-3

Products guided by the article

Product name:2,2,2-Trifluoro-1-[5-(2-methoxy-4-phenyl-4,5-dihydro-imidazole-1-sulfonyl)-2,3-dihydro-indol-1-yl]-ethanone

Cas No:203861-14-7

R&D Labs maybe for 203861-14-7

Shenzhen HwaGen Pharmaceutical Co., Ltd

website:http://www.rafflespt.com

Contact:+86-752-5538396

Address:Guangdong Huizhou China
Sinochem Jiangsu Co.,Ltd.

Contact:86-25-51817806

Address:No. 216, middle longpan road, jincheng tower, floor 21-22, nanjing ,china
Wuhan Yitongtai Science and Technology Co.,Ltd.

Contact:+86-27-88933550

Address:27th Fl. Bldg. 1, Shuian International Mansion, Heping Ave, Wuhan, Hubei, China
Beijing Zhongshuo Pharmaceutical T & D Co.,Ltd

Contact:0086-10-64430626

Address:ea No 16, HEPINGLI,DONGCHENG DISTRICT,BEIJING,P.R.CHINA.
Kunshan Yalong Trading Co,.Ltd

Contact:86-512-57621185

Address:805-807 Room Hongqiao Mansion ,1088 West Qianjin Road, Kunshan, Jiangsu，China

Relevant to this article

An enantiospecific synthesis of (+)-methyl epijasmonate and (-)-methyl cucurbate from L-glutamic acid

Doi:10.1016/S0040-4020(98)00069-6
(1998)
Synthesis of optically active arylene bis-alanine derivatives carrying orthogonal protecting groups

Doi:10.1016/S0957-4166(98)00014-7
(1998)
Synthesis of chiral β-aminophosphonates via Rh-catalyzed asymmetric hydrogenation of β-amido-vinylphosphonates

Doi:10.1016/j.tetasy.2008.04.019
(2008)
Addition of propargyltrimethylsilane to N-methyleneamine equivalents: Generation and electrophilic cyclization of vinylic carbocations

Doi:10.3987/COM-97-7943
(1997)
Electrosynthesis of β-trifluoromethylated O,S-acetal and α-(trifluoromethyl)acrylate derivatives from 2-ethoxycarbonyl-3,3,3-trifluoropropyl phenyl sulfide using a fluoride ion mediator

Doi:10.1016/S0022-1139(97)00147-4
(1998)
A mild deprotection procedure for tert-butyl esters and tert-butyl ethers using ZnBr₂ in methylene chloride

Doi:10.1016/S0040-4039(00)00300-2
(2000)

Article Doi