Synthesis and antitumor activity of 4-phenyl-1-arylsulfonyl imidazolidinones

DOI: 10.1016/S0960-894X(98)00261-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1547 - 1550 (1998)

Update date:2022-07-29

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Authors:

Jung, Sang-Hun

Lee, Hui-Soon

Song, Jae-Shin

Kim, Hwan-Mook

Han, Sang-Bae

Lee, Chang-Woo

Lee, Moonsun

Choi, Dong-Rack

Lee, Jung-Ah

Chung, Yong-Ho

Yoon, Sung-June

Moon, Eun-Yi

Hwang, Hyun-Sook

Seong, Seung-Kyoo

Lee, Dug-Keun

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Article abstract of DOI:10.1016/S0960-894X(98)00261-3

Novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones 3 synthesized show highly potent and broad cytotoxicities. Among them compound 3b (DW2143) exhibits much more potent cytotoxicities than doxorubicin and highly effective antitumor activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.

Full text of DOI:10.1016/S0960-894X(98)00261-3

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