Synthesis and antitumor activity of 4-phenyl-1-arylsulfonyl imidazolidinones

DOI: 10.1016/S0960-894X(98)00261-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1547 - 1550 (1998)

Update date:2022-07-29

Topics:

Authors:

Jung, Sang-Hun

Lee, Hui-Soon

Song, Jae-Shin

Kim, Hwan-Mook

Han, Sang-Bae

Lee, Chang-Woo

Lee, Moonsun

Choi, Dong-Rack

Lee, Jung-Ah

Chung, Yong-Ho

Yoon, Sung-June

Moon, Eun-Yi

Hwang, Hyun-Sook

Seong, Seung-Kyoo

Lee, Dug-Keun

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00261-3

Novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones 3 synthesized show highly potent and broad cytotoxicities. Among them compound 3b (DW2143) exhibits much more potent cytotoxicities than doxorubicin and highly effective antitumor activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.

Full text of DOI:10.1016/S0960-894X(98)00261-3

Products guided by the article

Product name:2,2,2-Trifluoro-1-[5-(2-methoxy-4-phenyl-4,5-dihydro-imidazole-1-sulfonyl)-2,3-dihydro-indol-1-yl]-ethanone

Cas No:203861-14-7

R&D Labs maybe for 203861-14-7

Yuan Shi(SuQian)Biotechnology Co.,Ltd

website:http://www.yuanshibio.com

Contact:+86-527-84226672

Address:jiangsu suqian
Evergreen Chemical Industry Ltd.

Contact:86-553-4918210

Address:6#2-602 Wanhaobailing
Changsha Huajing Powdery Material Technological Co., Ltd.

Contact:86-731-88879686

Address:Building 2, West Garden, Main Campus of Central South University, Changsha, Hunan Province, China
AllyChem Co., Ltd., Dalian, China（BBChem）

Contact:+86-411-62313318/62313328

Address:No.5 of Jinbin Road, Jinzhou New District, Dalian City, Liaoning Province, P.R.China
Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

website:http://www.jlpharms.com

Contact:86-571-86982636

Address:Rm A606, Fuyi Center, jianqiao street

Relevant to this article

An enantiospecific synthesis of (+)-methyl epijasmonate and (-)-methyl cucurbate from L-glutamic acid

Doi:10.1016/S0040-4020(98)00069-6
(1998)
Synthesis of optically active arylene bis-alanine derivatives carrying orthogonal protecting groups

Doi:10.1016/S0957-4166(98)00014-7
(1998)
Synthesis of chiral β-aminophosphonates via Rh-catalyzed asymmetric hydrogenation of β-amido-vinylphosphonates

Doi:10.1016/j.tetasy.2008.04.019
(2008)
Addition of propargyltrimethylsilane to N-methyleneamine equivalents: Generation and electrophilic cyclization of vinylic carbocations

Doi:10.3987/COM-97-7943
(1997)
Electrosynthesis of β-trifluoromethylated O,S-acetal and α-(trifluoromethyl)acrylate derivatives from 2-ethoxycarbonyl-3,3,3-trifluoropropyl phenyl sulfide using a fluoride ion mediator

Doi:10.1016/S0022-1139(97)00147-4
(1998)
A mild deprotection procedure for tert-butyl esters and tert-butyl ethers using ZnBr₂ in methylene chloride

Doi:10.1016/S0040-4039(00)00300-2
(2000)

Article Doi