Tetrahedron Letters p. 1099 - 1102 (1998)
Update date:2022-08-05
Topics:
Guo, Chuangxing
Fuchs
The protected aglycone (21e-β) of the potent anti-tumor agent OSW-1 (1) was synthesized in 9 steps from 5-androsten-3β-ol-17-one (10) in 55% overall yield. Key reactions involve ene installation of the side chain, regio and stereoselective dihydroxylation and diastereoselective reduction of the C16 ketone.
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Doi:10.1016/j.ejmech.2011.05.003
(2011)Doi:10.1080/00397911.2016.1230217
(2017)Doi:10.1021/ja973443k
(1998)Doi:10.1021/ja01013a053
(1968)Doi:10.1021/om971126g
(1998)Doi:10.1016/S0040-4039(98)00094-X
(1998)
